Holmby Hills South is the portion south of Sunset Boulevard that extends south to Club View Dr and east to Beverly Glen Boulevard and west of the Los Angeles Country Club; it is located within the Westwood Community Plan Area, but certain characteristics such as the absence of sidewalks and the presence of historic street lamps that are unique to Holmby Hills help to distinguish it from the remainder of Westwood.

Holmby Hills South is served by the Holmby Westwood Property Owners Association, which it shares with the rest of the northern Westwood area east of UCLA. However, in 2013, the Holmby Hills Homeowners Association Board decided to reach out to the homeowners south of Sunset (and east of Beverly Glen) to grow the Association with new members also residing in Holmby Hills having similar interests.

Holmby Hills South is home to some of the most famous estates in the world. The Manor "594 S Mapleton Dr" is undoubtedly at the top of that list with its 4.6 acres and unrivalled setting. The Playboy Mansion at 10236 Charing Cross Road would be considered more notable to some as this iconic property has been famous, or infamous for decades.

Other celebrities include Lex Barker at 120 S Mapleton Dr, Humphrey Bogart & Lauren Bacall at 232 S Mapleton Dr. Joan Bennett at 515 S Mapleton Dr hired architect Wallace Neff to design this French Provincial house in 1937. Six years later, it nearly burned down. It took a full year to rebuild it to match the original.

Holmby Hills South is home to Holmby Park and the Holmby Park Lawn Bowling Park.